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The correct region located in the southern part of Alsace is Haut Rhin. This region is well-known for its rich viticultural heritage, producing a variety of excellent wines, particularly from grape varieties such as Riesling, Gewürztraminer, and Pinot Gris. Haut Rhin encompasses picturesque villages and vineyards that benefit from a favorable climate and diverse soil types, contributing to the quality of the wines produced here.

In contrast, Bas Rhin is situated to the north of Haut Rhin, making it geographically the northern region of Alsace. Alsace Centrale does not exist as a formal wine region; the name could imply an area in the middle, but it lacks the recognition of the traditionally defined Alsace wine regions. Alsace Septentrionale, referring to the northern part of Alsace, also does not accurately describe the southern region of Alsace. Therefore, Haut Rhin is definitively recognized as the correct answer, representing the southern part of Alsace and its acclaimed wine production area.